Bone tumours
The basic principles about how an osseous lesion on x-ray should be evaluated and described.
- Indication / technique
- Normale Anatomy
- Checklist -Overview
- Checklist - Age & Location
- Checklist - Aspect Lesion
- Checklist - Periosteal Reactions
- Checklist - Soft Tissue & Solitary/Multiple
- Pathology - General
- Bone metastases
- Chondroid tumours
- Osteoid tumours
- Fibrous Bone Lesions
- Cystic Bone Lesions
- Giant Cell Tumour of Bone
- Paget Disease
- Multiple Myeloma
Paget’s disease
Paget’s disease of bone is a disease of the osteoclasts in which bone remodelling is disrupted. The exact disease mechanism is not fully understood, but the cause is thought to lie with a viral infection and/or with genetic predisposition. Because the osteoclasts ‘run wild’ (become overactive) and osteoblastic activity is triggered as a result, the disease can manifest in both lytic and sclerotic changes. One of the first signs of Paget’s disease is increased serum alkaline phosphatase levels. This in combination with normal calcium, phosphate and transaminase levels in an older patient is already suggestive of the disease.
Interested?
Learn everything about Bone tumours
Text
drs. A. van der Plas (MSK radiologist Maastricht UMC+)
With special thanks to:
drs. W. Huijgen (MSK radiologist HagaZiekenhuis Den Haag)
Illustrations
drs. A. van der Plas (MSK radiologist Maastricht UMC+)
Sources:
- A.M. Davies et al. Imaging of Bone Tumors and Tumor-Like Lesions (2009)
- A. Franchi; Epidemiology and classification of bone tumors. Clin Cases Miner Bone Metab. 2012.
21/10/2018
(All the work (text, illustrations, visual elements) seen on this website is copyright by Radiology Expert.
It may not be used without written permission of Radiology Expert).